Does the linear Sry transcript function as a ceRNA for miR-138? The sense of antisense

نویسندگان

  • Javier Tadeo Granados-Riveron
  • Guillermo Aquino-Jarquin
  • Amy Pasquinelli
  • Guillermo Aquino-Jarquin
  • Gordon Carmichael
چکیده

Recently, the sex determining region Y ( Sry) and the cerebellar degeneration-related protein 1 ( CDR1as) RNA transcripts have been described to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7, respectively. A special feature of the Sry gene is its ability to generate linear and circular transcripts, both transcribed in the sense orientation. Here we remark that both sense (e.g. Sry RNA) and antisense (e.g. CDR1as) transcripts could circularize and behave as miRNAs sponges, and importantly, that also protein-coding segments of mRNAs could also assume this role. Thus, it is reasonable to think that the linear Sry sense transcript could additionally act as a miRNA sponge, or as an endogenous competing RNA for miR-138.

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Does the linear transcript function as a ceRNA for Sry miR-138? The sense of antisense [version 2; referees: 2 approved]

Recently, the sex determining region Y ( ) and the cerebellar Sry degeneration-related protein 1 ( ) RNA transcripts have been described CDR1as to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7, respectively. A special feature of the gene is its ability to Sry generate linear and circul...

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2014